
Inside the DNA Repair Lab
Led By: Jeanette Sutherland, PhD, and students Gary Xavier Valdez and Sophia Ruisi
All living cells are constantly having their DNA damaged and have to repair it. Without DNA repair, cancer can take over. The BRCA2 gene plays a major role in fixing damaged DNA — but when it’s mutated, the repair process weakens, increasing the risk of breast cancer.
At Farmingdale State College, Jeanette Sutherland, PhD and her students Gary Xavier Valdez and Sophia Ruisi are using a microbe with a gene equivalent to BRCA2 to study how specific mutations impact DNA repair. By introducing mutations in the lab and analyzing how proteins bind to DNA, they’re uncovering the molecular mechanics behind cancer risk — contributing to the basic science that drives personalized treatments in the future.
This ongoing research, started during Dr. Sutherland’s postdoctoral work at Weill Cornell Medicine, and has continued at FSC. Recent studies were published in 2024, and more findings are being prepared for an additional publication.





